Science at the Edge Seminar
Speaker: Jiali Gao, Department of Chemistry, University of Minnesota, and Jilin University, Changchun, China
Title: Control of Water by Protein Functional Dynamics in Two Photoreceptors
Refreshments at 11:15 am.
Date: Fri, 10 Feb 2017, 11:30 am - 12:30 pm
Location: 1400 BPS Bldg.
UVR8 and the LOV domain are photoreceptor proteins. Up on photo-excitation, the UVR8 dimer dissociates into monomers and the LOV domain undergoes conformation change, both triggering a range of cell functions. Computation studies show that water plays an integral role of the dimer dissociation process of UVR8 and the dark-state recovery of the covalently linked photoproduct in the LOV domain. In this talk, I will describe computational methods that have been developed to study charge transfer processes in the ultrafast photochemical processes, and analyses of molecular dynamics trajectories that reveal the interplay of protein conformational dynamics and access of water in the active centers of the proteins.